AG1024 | HY-10253

AG1024 (Tyrphostin AG 1024) is a reversible, competitive and selective IGF-1R inhibitor with an IC50 of 7 μM. AG1024 inhibits phosphorylation of IR (IC50=57 μM). AG1024 induces apoptosis and has anti-cancer activity[1][2].

IC50 & Target :

IC50: 7 μM (IGF1R) and 57 μM (IR)[1][2]

In Vitro:

AG1024 (Tyrphostin AG 1024; 2-10 μM; 1-5 days) shows a dose-dependent inhibition of cell proliferation^[1].
AG1024 (1-5 μM; 1-3 days) induces UT7-9 and Baf3-p210 cells apoptosis^[1].
AG1024 (2 μM; 6, 12 hours) downregulates phospho-Akt, Bcr-Abl and upregulates DNA-PKcs^[1].

In Vivo:

AG1024 (Tyrphostin AG 1024; 30 μg; i.p.; per day; for 2 weeks) significantly delays the tumour growth^[1].

Molecular weight:

305.17

Formula:

C₁₄H₁₃BrN₂O

SMILES:

N#C/C(C#N)=C\C1=CC(C(C)(C)C)=C(O)C(Br)=C1

Storage: