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Antibodies

Initiation Factors

Kinase Substrates

Modulator Proteins

Protein Kinases

Protein Phosphatases

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Distributors

GloboZymes is a leading provider of top-quality signal transduction products, some of which are unique to our company. Our purified protein kinases, protein phosphatases, protein kinase substrates, modulator proteins, protein synthesis initiation factors, and purified antibodies are some of the best available. Our antibodies are effective for the detection of some of the rarest protein kinases, protein phosphatases, modulator proteins and initiation factors.  Our products are distributed worldwide. You can buy GloboZymes top-quality products directly from us. Alternatively, you can purchase our products through any one of our international distributors.

The following is a partial list of international distributors of our products:

Sapphire Bioscience Pty. Ltd.
126 Cope Street
Waterloo NSW 2017, Australia
Toll Free: 800-062-088
Tel: +61 2 9698 2022
Fax: +61 2 9698 1022
sales@sapphirebioscience.com

Holzel Diagnostika Handels GmbH
Hohenzollernring 38
50672 Koln
Deutschland
info@hoelzel.de

TEBU-BIO NV
Alexander Franckstraat 196
B-2530 Boechout
Tel: 03-454-0066
Fax: 03-454-1888
belgium@tebu-bio.com

Cedarlane
4410 Paletta Court
Burlington, ON
Toll Free: 1-800-268-5058
Tel: 289-288-0001
Fax: 289-288-0020

Dakewe
Unit 2D, Jialitai Bldg
6 Yanshan Road Shekou
Nanshan
Shenzhen 518067, China
Tel: +86-755-26869146
Fax 86-755-26869149
info@dakewe.com

Nordic Biosite ApS
Toldbodgade 18, 5
1254 København K
Denmark
Tel: 800 10595
Fax +46 (0)8 756 94 90
info@biosite.se

News

Introduction

Over the past nineteen years, GloboZymes has established itself as a leading provider of top quality protein kinasesprotein kinase substratesprotein phosphatasesmodulator proteinsprotein synthesis initiation factors and antibodies. As a worldwide provider of purified signal transduction enzymes, regulatory proteins and antibodies, we assure quality above all. Below are just a few examples of the top quality protein kinase preparations we supply.

Purified GST-tagged PAK1

PAK1 is a 65-68 kDa Group I member of a protein serine/threonine kinase family whose activity is stimulated by the Rho family small GTPases Rac and Cdc42. PAKs regulate numerous cellular processes. These include cell morphology and cytoskeleton organization, cell motility, apoptosis, neuronal functions, cell cycle progression and viral replication. GST-PAK1 exhibits an apparent Mr ~ 100 kDa on SDS-PAGE.

Introduction
Eukaryotic Initiation Factor 4E (eIF4E) is a rate-limiting initiation factor in protein synthesis. It directs ribosomes to the cap structure of mRNAs. eIF4E is a 217 amino acid ~ 24-kD polypeptide that exists as a free form, as part of the active eIF4F pre-initiation complex, or as an inactive complex with eIF4E binding proteins (4E-BPs). In their dephosphorylated form, 4E-BPs inhibit assembly of the eIF4F complex and hence cap-dependent translation. Once phosphorylated by the mTOR kinase, the 4EBPs release eIF4E which can then associate with the eIF4F complex. The other subunits of the eIF4F complex are a 47-kD polypeptide, termed eIF4A, that possesses ATPase and RNA helicase activities, and a 220-kD scaffolding polypeptide, eIF4G.
 
Phosphorylation of eIF4E
eIF4E is phosphorylated at Ser209 in cells in response to insulin and other growth factors. This phosphorylation increases the affinity of eIF4E for capped mRNA.  …
 

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