Life Science

Life Science

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  • Luminespib | HY-10215

    Luminespib | HY-10215

    Gentaur

    Luminespib | HY-10215 Luminespib (VER-52296) is a potent HSP90 inhibitor with IC50s of 7.8 and 21 nM for HSP90α and HSP90β, respectively. IC50 & Target: In Vitro: Luminespib is a potent and selective HSP90 inhibitor, with IC50s and Kis of...
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  • BIIB021 | HY-10212

    BIIB021 | HY-10212

    Gentaur

    BIIB021 | HY-10212 BIIB021 (CNF2024) is an orally active, fully synthetic inhibitor of HSP90 with a Ki and an EC50 of 1.7 nM and 38 nM, respectively. IC50 & Target: In Vitro: BIIB021 binds in the ATP-binding pocket of Hsp90, interferes with Hsp90...
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  • Tanespimycin | HY-10211

    Tanespimycin | HY-10211

    Gentaur

    Tanespimycin | HY-10211 Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin depletes cellular STK38/NDR1 and reduces...
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  • Retaspimycin Hydrochloride | HY-10210

    Retaspimycin Hydrochloride | HY-10210

    Gentaur

    Retaspimycin Hydrochloride | HY-10210 Retaspimycin Hydrochloride is a potent inhibitor of Hsp90 with EC50s of 119 nM for both Hsp90 and Grp9. IC50 & Target: In Vitro: Retaspimycin (IPI-504) is a novel and highly soluble analog of 17AAG, an inhibitor...
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  • Motesanib Diphosphate | HY-10229

    Motesanib Diphosphate | HY-10229

    Gentaur

    Motesanib Diphosphate | HY-10229 Motesanib Diphosphate (AMG 706 Diphosphate) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is approximately 10-fold more selective...
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  • Motesanib | HY-10228

    Motesanib | HY-10228

    Gentaur

    Motesanib | HY-10228 Motesanib (AMG 706) is a potent ATP-competitive inhibitor of VEGFR1/2/3 with IC50s of 2 nM/3 nM/6 nM, respectively, and has similar activity against Kit, and is appr 10-fold more selective for VEGFR than PDGFR and Ret. IC50 &...
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  • Bortezomib | HY-10227

    Bortezomib | HY-10227

    Gentaur

    Bortezomib | HY-10227 Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits...
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  • Belinostat | HY-10225

    Belinostat | HY-10225

    Gentaur

    Belinostat | HY-10225 Belinostat (PXD101; PX105684) is a potent HDAC inhibitor with an IC50 of 27 nM in HeLa cell extracts. IC50 & Target: In Vitro: Belinostat (PXD101) induces a concentration-dependent (0.2-5 μM) increase in acetylation of...
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  • Panobinostat | HY-10224

    Panobinostat | HY-10224

    Gentaur

    Panobinostat | HY-10224 Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selective HDAC inhibitor, and has antineoplastic activities. Panobinostat induces HIV-1 virus production even at low concentration range 8-31 nM, stimulates HIV-1...
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  • CUDC-101 | HY-10223

    CUDC-101 | HY-10223

    Gentaur

    CUDC-101 | HY-10223 CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC50s of 4.4, 2.4, and 15.7 nM, respectively. IC50 & Target: In Vitro: CUDC-101 inhibits both class I and class II HDACs, but not class III, Sir-type HDACs. CUDC-101...
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  • Ixabepilone | HY-10222

    Ixabepilone | HY-10222

    Gentaur

    Ixabepilone | HY-10222 Ixabepilone (BMS-247550) is an orally bioavailable microtubule inhibitor, which binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arrests cells in the G2-M phase of the cell cycle and...
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  • Simeprevir | HY-10241

    Simeprevir | HY-10241

    Gentaur

    Simeprevir | HY-10241 Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently...
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