L-Buthionine-sulfoximine is a sulfoximine and irreversible inhibitor of gamma-glutamylcysteine synthetase.

Studies show methylglyoxal (MG) activated caspase-3 is enhanced in the presence of BSO. It has been reported that BSO can augment HIV-1 activation through class I HDACIs, and that it can sensitize human breast cancer cells that are anti-hormone resistant to estrogen-induced apoptosis.

Applications

Buthionine sulfoximine may also be used to increase the sensitivity of parasites to oxidative antiparasitic drugs.

Molecular Weight: 222.30 Da

Chemical Formula: C₈H₁₈N₂O₃S

Solubility: Aqueous Acid, Water

Storage Temperature: -20°C