Chlorhexidine diacetate is a bis(biguanide) compound with broad spectrum antimicrobial properties that make it effective against both Gram-positive and Gram-negative bacteria. In solution, positively charged chlorhexidine binds to cell wall phospholipids, causing bacterial cell walls to rupture and ultimately leading to cell death. Depending on concentration, the compound may exert either a bacteriostatic or bactericidal effect.

Upon application in vitro, chlorhexidine can kill nearly 100% of Gram-positive and Gram-negative bacteria within 30 seconds. Since chlorhexidine formulations can destroy the majority of categories of microbes, there is limited risk for the development of an opportunistic infections.

Applications

• Chlorhexidine diacetate is used regularly both as a topical antiseptic and as an antimicrobial component of mouthwash.
• Can be used to clean wounds, prevent dental plaque and treat yeast infections of the mouth.
• Used in more rigorous medical applications, both as an antimicrobial agent for preventing infection after catheterization and for disinfecting medical and surgical devices.
• Shown to be effective in inactivating human immunodeficiency virus (HIV).
• Preparation of a 0.5% chlorhexidine diacetate solution for cleansing cow teats after milking.

Molecular Weight: 625.55 Da

Chemical Formula: C₂₂H₃₀Cl₂N₁₀ • 2C₂H₄O₂

Solubility: Clear, colorless to faint yellow

Storage Temperature: Room Temperature