C4b-Binding Protein Beta Chain (C4BPB) Antibody | abx004862

C4b-Binding Protein Beta Chain (C4BPB) Antibody is a Rabbit Polyclonal antibody against C4b-Binding Protein Beta Chain (C4BPB). This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants.

Target: C4b-Binding Protein Beta Chain (C4BPB)

Clonality: Polyclonal

Reactivity:Human, Mouse, Rat

Tested Applications: WB, IHC, IF/ICC

Host: Rabbit

Recommended dilutions: WB: 1/500 - 1/2000, IHC: 1/50 - 1/100, IF/ICC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user.

Conjugation: Unconjugated

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 18-251 of human C4BPB.

Isotype: IgG

Form: Liquid

Purification: Purified by affinity chromatography.

Storage: Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.