Chimeric Anti EBOV (C6D8)
Venezuelan equine encephalitis virus replicons encoding Zaire ebolavirus (ZEBOV) glycoprotein (GP) was used to generate the original mouse monoclonal antibody.
A murine / human chimeric IgG produced in N. benthamiana and is reactive to ZEBOV GP. The antibody detects GP in virus-like particles (VLP) and recombinant GP without the transmembrane region (rGPdTM).
100 µg is supplied at a concentration of 3.85 mg/mL. No preservative is added.
Antibody is purified using immobilized protein A.
Murine variable, human constant of the IgG1 isotype.
The antibody can be used for detection of ZEBOV GP. A mixture of all three anti-ZEBOV GP chimeric antibodies was protective against lethal challenge in a nonhuman primate study (Olinger et al. PNAS 2012, vol. 109, no. 44, 18030-18035).
Assay-dependent dilution. Internal QC demonstrates good detection when using antibody at 0.5 µg/mL.
No cross-reactivity was observed to Sudan ebolavirus (SEBOV) or Marburg Virus (MARV) VLP or rGPdTM
2-3 weeks +4oC, -20◦C long term