AKT Kinase Inhibitor | HY-10249A

AKT Kinase Inhibitor is an Akt kinase inhibitor with anti-tumor activity[1].

IC50 & Target :

Akt

In Vitro:

The effect of selective inhibition of Akt in proliferating cells expressing Trop-2 is studied. Akt inhibition, either by silencing or with specific drugs, induces a marked decrease in cell proliferation in cells expressing Trop-2, in a dose-dependent fashion^[1].

In Vivo:

Trop-2 expressing tumors subcutaneously injected in animal models show a striking reduction of growth following treatment with specific drugs that inhibit Akt activity. Therefore Akt has a central functional role in mediating the Trop-2-dependent growth stimulus^[1].

Molecular weight:

357.37

Formula:

C₁₆H₁₉N₇O₃

SMILES:

OCC#CC1=NC=C(C2=C1N=C(N2CC)C3=NON=C3N)OCCCN

Storage: