Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit | abx572602

Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5) concentrations in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Introduction: A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene. ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage. ADAMTS5 may also have a role in the pathogenesis of human osteoarthritis.
Target: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5 (ADAMTS5)
Reactivity: Human
Tested Applications: ELISA
Recommended dilutions: Optimal dilutions/concentrations should be determined by the end user.
Storage: Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Validity: The validity for this kit is 6 months.
Stability: The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout.