DEK Oncoprotein

Source: GST-tagged recombinant human kidney produced in E. coli.

Purity: > 90% by SDS-PAGE, apparent Mr ~ 70-kDa.

Supplied: 1 μg in 50 μl 50 mM Tris-HCl pH 7.0 buffer containing 14 mM β-mercaptoethanol, 1 mM benzamidine, 0.1 mM phenylmethanesulfonyl fluoride, 1 mM EDTA and 10% glycerol. Maintain preparations in aliquots at -70° C. Avoid repeated thawing.

Synonym: GST-DEK oncoprotein

Background: DEK is a nuclear phosphoprotein of apparent Mr ~ 43 kDa that is fused to the nucleoporin CAN as a result of a recurrent (6;9) chromosomal translocation in a subset of acute myeloid leukemias and myelodysplastic syndrome. DEK has also been identified as an autoimmune antigen in juvenile rheumatoid arthritis and other rheumatic diseases. It changes the topology of DNA by introducing constrained positive supercoils into protein-free and chromatin-associated DNA. DEK also associates with the transcriptional co-repressor Human Daxx, the SRm160 splicing coactivator and the HIV-2 enhancer. DEK exhibits some structural similarity to I1PP2A (GLO140-001) and I2PP2A (GLO141-001). Interestingly, I2PP2A also occurs as a fusion protein with CAN in acute undifferentiated leukemia suggesting a common mechanism of action.


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