Description: Anti-PP2AC is a polyclonal antiserum raised in rabbits to the catalytic subunit of bovine kidney protein phosphatase 2A (GLO130-GLO132). The antibody solution is useful for Western blotting, for example, at 1:1000 dilution with 30 μg bovine liver extracts.
Synonym: Polyclonal Antibody to the Catalytic Subunit of Protein Phosphatase 2A; Anti-PP2AC
Background: Protein phosphatase 2A (PP2A, GLO130-GLO132) is a divalent cation-independent protein serine/ threonine phosphatase involved in regulating numerous cellular processes including the cell cycle, growth and differentiation. Physiological targets of PP2A include cell surface receptors and ion channels, protein kinases involved in mitogenic signaling and the cell cycle, key regulatory enzymes and proteins involved in metabolism, as well as numerous transcription factors. The phosphatase has been implicated as a growth suppressor. It is inhibited potently by tumor promoters such as okadaic acid and by I1PP2A (GLO140-001) and I2PP2A (SET) (GLO141-001), two naturally-occurring cancer-associated cellular proteins. Additionally, the SV40 small t antigen replaces the B subunit during viral transformation and subverts the physiological function of a subset of PP2A complexes in a substrate selective manner.
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References: Biochem J 287, 1019-1022 ♦ Proc Natl Acad Sci USA 90, 2500-2504 ♦ Trends Cell Biol 4, 287-291 ♦ Ann Rev Cell Biol 10, 55-86 ♦ Biochem J 353, 417
Related Products: Anti-PP2AC (200 μl) ♦ PP2AC Detection Kit ♦ PP2A1 (1 μg) ♦ PP2A1 (5 μg) ♦ PP2A2 (1 μg) ♦ PP2A2 (5 μg) ♦ PP2AC (1 μg)