Phosphorylation of I1PP2A(a) at Tyrosine Residues in vivo
Recent studies by Yu L-G et al (J Biol Chem 279, 41377) have shown that treatment of HT29 colon cancer cells with the antiproliferative lectin, jacalin, stimulates tyrosine phosphorylation of I1PP2A(a), which results in dissociation of PP2A from the inhibitor protein and activation of the phosphatase followed by inactivation of MEK1/2 and ERK1/2 ... more info